Every woman knows the rhythm of her own cycle. When that breaks, the bleeding lasts for too long, and it comes with extra pain. This is often called Dysfunctional Uterine Bleeding (DUB). There are top gynecological medicines for dysfunctional uterine bleeding to treat this problem.
DUB is not a rare condition; abnormal uterine bleeding affects approximately 1 in 5 women. In India, nearly 30% of all women consult a gynecologist for this reason. Studies also show DUB is more prevalent at the two extremes of reproductive life during adolescence and perimenopausal years. Let’s discuss DUB in detail and the best gynae medicines for dysfunctional uterine bleeding available in the market.
What is DUB?
Dysfunctional Uterine bleeding (DUB) is defined as abnormal bleeding from the uterus that does not have an anatomical or systemic cause. This is a problem of hormones, when there is a disturbance of the delicate balance between the two major hormones involved in menstruation (estrogen and progesterone). It results in irregular and excessively heavy bleeding.
Types of DUB
DUB can be divided into 2 types (one type is more common):
1) Anovulatory (no ovulation): it is usually caused by polycystic ovary syndrome (PCOS), thyroid problems, and/or hormonal imbalance.
2) Ovulatory DUB (occurs in the presence of regular ovulation): Symptoms include heavy menstrual bleeding.
List of Top Gynae Medicines for Dysfunctional Uterine Bleeding (DUB)
TRAPRES-500 SR
Composition: Tranexamic Acids 500 mgs SR (Sustained Release) Tablets
Marketer: Adorshea
TRAPR-SR contains 500 mg Tranexamic Acid (500) in a sustained release formulation, which has been clinically proven for treating women with heavy menstrual bleeding with DIBU.
Tranexamic acid is an antithrombotic that blocks an enzyme that breaks down blood clotting. It also helps to reduce the amount of menstrual flow. Tranexamic acid is not a hormone, so it is often preferred by women who choose to avoid using hormone therapy.
Tranexamic acid can reduce monthly blood loss between 40-50% and is listed as a first-line option for treating heavy bleeding. The economic benefits of this SR (Sustained Release) formulation supply a consistently more reliable therapeutic dose at any given time.
2. DUBALEX N10CR
Composition: Norethisterone Acetate 10mg Tablets
Marketer: Adorshea
DUBALEX N10CR is one of the most common medicines prescribed in India for treating DUB. Norethisterone Acetate is a synthetic progesterone (progestin) that contains 10mg of the drug. It stabilises the endometrial lining and regulates the menstrual cycle.
Anovulatory DUB occurs when there is a lack of ovulation. It means that no progesterone will be produced. The high levels of estrogen can lead to over-stimulation of the uterus and build-up of the endometrial lining. The synthetic progesterone (norethisterone) can be used to correct this balance. It will stop the abnormal bleeding and assist the body in regulating the cycle.
Norethisterone is also used to treat endometriosis, secondary amenorrhoea, and some hormone-dependent cancers using higher doses. Gynaecologists also frequently prescribe norethisterone to induce or delay menstruation in a controlled manner.
3. Adorgest 300 SR Tablets
Composition: Natural Micronized Progesterone 200mg Sustained Release Tablets
Marketer: Adorshea
Adorgest 300 SR has the same function as synthetic progestins. It does not have several side effects because its molecular structure is more similar to that of the human body. The micronization process decreases the size of progesterone and increases the bioavailability of the progesterone within the body.
Adorgest 300 SR is used to treat irregularities in menstruation (DUB) due to insufficient amounts of Progesterone in females. Due to being natural in origin, Adorgest 200 SR has fewer side effects associated with a progestin of synthetic origin.
4. DUBALEX
Composition: Ormeloxifene (60 mg)
Marketer: Adorshea
Ormeloxifene is a Selective Estrogen Receptor Modulator (SERM), and it is well accepted for the treatment of DUB in women with heavy bleeding or menorrhagia. This tablet does not affect other hormones and requires only one dose weekly after an initial two doses. This medication helps to decrease the growth of the endometrial lining (uter
us). It also decreases the amount of bleeding during the period.
5. DydroTru
Composition: Dydrogesterone 20 mg SR
Marketer: Womaura
This medicine is used when immediate bleeding control is required for the treatment of DUB. This medicine can provide rapid control of abnormal bleeding (within 24-48 hours). This tablet provides an immediate and highly effective dose of aqueous progesterone to help control bleeding. DydroTru is widely used in hospitals or emergencies.
6. Drotikind-M Tablets
Composition: Drotaverine + Mefenamic Acid Tablets
Marketer: Mankind Pharma Ltd
Drotikind-M Tablets effectively treat two primary concerns associated with DUB, such as excessive bleeding and cramping in the uterus. Mefenamic Acid is classified as an NSAID, which helps reduce the production of prostaglandins and the chemicals that cause both heavy menstrual bleeding and pain. Drotaverine acts as an antispasmodic that relaxes the contractions of the muscles in the uterus. The efficacy of Mefenamic Acid is a good medicine for women who experience ovulatory DUB.
7. Duphaston Tablets
Composition: Dydrogesterone 10mg Tablets
Marketer: Abbott India Ltd
Duphaston Tablets are a structured form of progestogen with a similar structure to natural progesterone. Dydrogesterone has been used for several decades to manage menstrual irregularities, abnormal uterine bleeding, and progesterone deficiency. Dydrogesterone is classified as a synthetic progestin and does not have any androgen, estrogen, or corticoids.
8. Novelon
Composition: Desogestrel + Ethinylestradiol
Marketer: Organon
Desogestrel + Ethinylestradiol tablets are some of the most versatile forms of contraception available to gynaecologists to treat DUB. The dual action method of using these contraceptives is to first suppress the regrowth of the endometrium in DUB from hormone fluctuations. Additionally, this method is very effective in treating adolescent DUB and abnormal bleeding from PCOS.
9. Lupinfer Tablets
Composition: Iron Pyrophosphate Liposomal + Vit C + B12 + Folic Acid
Marketer: Lupin Ltd
This medication doesn’t stop the bleeding from DUB directly. This is essential in a total treatment plan in managing DUB, because the chronic DUB bleeding creates chronic iron deficiency anemia in the majority of women who suffer from chronic DUB.
Lupinfer medicine is the next generation form of iron products with better absorption rates and much fewer side effects than the traditional iron salts.
10. Ulitas
Composition: Ulipristal Acetate 5 mg
Marketer: Intas Pharmaceuticals Ltd
Ulipristal Acetate 5mg is an SPRM and works primarily by acting on the endometrium and myometrium. Although it is mainly use in the management of uterine fibroids. This medicine is also very effective in the management of DUB when associated with fibroids or endometrial hyperplasia.
Final Thoughts!
Dysfunctional Uterine Bleeding is extremely general but it is a treatable disorder. If diagnosed appropriately and with the appropriate therapy. Additionally, all women should be able to resume normal menses without needing surgical procedures. The therapeutic options mentioned below can assist in managing DUB by reducing the acute bleeding, balancing hormones, and treating anemia.
Be sure to consult with your qualified gynecologist prior to beginning any form of treatment. A gynecologist will prescribe according to your age and overall health profile. Contact us for more information about the medicines:
Adorshea Bioceutics: SCO 338-339, 1st and 2nd floor, Swastik Vihar, Patiala Road, SAS NAGAR, 140603, PUNJAB
Call: +91-9877530744, +91-6280185695
Gmail: adorshea19@gmail.com